欧博官网2025–2026 COVID-19 Vaccination Guidance
COVID-19 vaccination is recommended for all adults ages 65 years and older based on individual-based decision-making (also known as shared clinical decision-making). For people ages 6 months–64 years, vaccination is recommended based on individual-based decision-making (also known as shared clinical decision-making)—with an emphasis that the risk-benefit of vaccination is most favorable for individuals who are at an increased risk for severe COVID-19 disease and lowest for individuals who are not at an increased risk, according to the CDC list of COVID-19 risk factors. In addition to the CDC list, the Moderna (Spikevax) package insert states that prematurity (birth at <37 weeks gestational age) has been associated with COVID-19-related hospitalizations in children ages 6–23 months.
Additionally, some people may be at increased risk for SARS-CoV-2 infection including healthcare workers and residents and employees in long-term care facilities and other residential congregate settings.
The 2025–2026 COVID-19 vaccination schedule is detailed in . The recommended vaccine and number of 2025–2026 COVID-19 vaccine doses are based on age and vaccination history.
Key updates to the 2025–2026 COVID-19 vaccination schedule
For children ages 6 months–4 years, only Moderna (Spikevax) COVID-19 Vaccine is approved for use; Pfizer-BioNTech COVID-19 Vaccine is no longer authorized for this age group.
Novavax COVID-19 Vaccine, approved for people ages 12 years and older, is administered as a single dose for initial vaccination.
Moderna (mNexspike) COVID-19 Vaccine is approved for people ages 12 years and older.
Table 1: 2025–2026 COVID-19 vaccination schedule, November 4, 2025 1a: Ages 6–23 months
NOTE
In Table 1a, Moderna refers to Spikevax, the only COVID-19 vaccine approved for this age group.
Children ages 6–23 months previously vaccinated with Pfizer-BioNTech COVID-19 Vaccine .
COVID-19 vaccination history before 2025–2026 vaccine*
Number of 2025–2026 doses indicated
Recommended 2025–2026 vaccine† and interval between doses
Administer initial series with 2025–2026 vaccine 2025–2026 Dose 2 (Moderna): 4–8 weeks after 2025–2026 Dose 1‡ Complete initial series with 2025–2026 vaccine 2025–2026 Dose 2 (Moderna): At least 4 weeks after 2025–2026 Dose 1 Administer 1 dose of 2025–2026 vaccine
Unvaccinated:
Unvaccinated
2
2025–2026 Dose 1 (Moderna): Day 0
Initiated but did not complete the initial series before 2025–2026 vaccine:
1 dose Moderna
1
2025–2026 Dose 1 (Moderna): 4–8 weeks after last dose‡
1 dose Pfizer-BioNTech
2
2025–2026 Dose 1 (Moderna): 3–8 weeks after last dose‡
2 doses Pfizer-BioNTech
1
2025–2026 Dose 1 (Moderna): At least 8 weeks after last dose
Completed the initial series before 2025–2026 vaccine:
2 or more doses Moderna or 3 or more doses Pfizer-BioNTech
1
2025–2026 Dose 1 (Moderna): At least 8 weeks after last dose
*COVID-19 vaccination history refers to all doses of COVID-19 vaccine from any manufacturer received before the availability of the 2025–2026 COVID-19 vaccines.
†Dosage for Moderna (Spikevax): 0.25 mL/25 ug.
‡An between the first and second COVID-19 vaccine doses (i.e., extended interval) might reduce the rare risk of myocarditis and pericarditis associated with COVID-19 vaccines.
1b: Ages 2–4 yearsNOTE
In Table 1b, Moderna refers to Spikevax, the only COVID-19 vaccine approved for this age group.
Moderna (Spikevax) is now administered to this age group as a single dose regardless of COVID-19 vaccination history.
See footnote* for guidance on children who transition from age 23 months to 2 years during initial vaccination with 2025–2026 vaccine.
COVID-19 vaccination history before 2025–2026 vaccine†
Number of 2025–2026 doses indicated
Recommended 2025–2026 vaccine‡ and interval between doses
Administer initial vaccination with 2025–2026 vaccine Administer 1 dose of 2025–2026 vaccine
Unvaccinated:
Unvaccinated
1
2025–2026 Dose 1 (Moderna): Day 0
Previously vaccinated before 2025–2026 vaccine:
1 or more doses mRNA (Moderna or Pfizer-BioNTech) vaccine
1
2025–2026 Dose 1 (Moderna): At least 8 weeks after last dose
*Children who transition from age 23 months to age 2 years during the initial vaccination with 2025–2026 vaccine (i.e., after they received Dose 1 but before Dose 2) should receive 1 dose of Moderna (Spikevax) after Dose 1.
†COVID-19 vaccination history refers to all doses of COVID-19 vaccine from any manufacturer received before the availability of the 2025–2026 COVID-19 vaccines.
‡Dosage for Moderna (Spikevax): 0.25 mL/25 ug.
1c: Ages 5–11 yearsNOTE
Moderna (Spikevax) and Pfizer-BioNTech COVID-19 vaccines are approved for use in this age group.
In Table 1c, Moderna refers to Spikevax.
COVID-19 vaccination history before 2025–2026 vaccine*
Number of 2025–2026 doses indicated
Recommended 2025–2026 vaccine† and interval between doses
Administer 1 dose of 2025–2026 vaccine Administer 1 dose of 2025–2026 vaccine
Unvaccinated:
Unvaccinated
1
2025–2026 Dose 1 (Moderna or Pfizer-BioNTech): Day 0
Previously vaccinated before 2025–2026 vaccine:
1 or more doses mRNA (Moderna or Pfizer-BioNTech) vaccine
1
2025–2026 Dose 1 (Moderna or Pfizer-BioNTech): At least 8 weeks after last dose
*COVID-19 vaccination history refers to all doses of COVID-19 vaccine from any manufacturer received before the availability of the 2025–2026 COVID-19 vaccines.
†Dosage for Moderna (Spikevax): 0.25 mL/25 ug; dosage for Pfizer-BioNTech: 0.3 mL/10 ug.
1d: Ages 12–64 yearsNOTE
Moderna (mNexspike), Moderna (Spikevax), Novavax, and Pfizer-BioNTech COVID-19 vaccines are approved for this age group.
Novavax is administered as a single dose for initial vaccination.
COVID-19 vaccination history before 2025–2026 vaccine*
Number of 2025–2026 doses indicated
Recommended 2025–2026 vaccine† and interval between doses
Administer 1 dose of 2025–2026 vaccine Administer 1 dose of 2025–2026 vaccine
Unvaccinated:
Unvaccinated
1
2025–2026 Dose 1 (Moderna, Novavax, or Pfizer-BioNTech): Day 0
Previously vaccinated before 2025–2026 vaccine:
1 or more doses any COVID-19 vaccine (Moderna, Novavax, or Pfizer-BioNTech)
1
2025–2026 Dose 1 (Moderna [Spikevax], Novavax, or Pfizer-BioNTech): At least 8 weeks after last dose; (Moderna [mNexspike]): At least 3 months after last dose‡
*COVID-19 vaccination history refers to all doses of COVID-19 vaccine from any manufacturer received before the availability of the 2025–2026 COVID-19 vaccines.
†Dosage for Moderna (mNexspike): 0.2 mL/10 ug; dosage for Moderna (Spikevax): 0.5 mL/50 ug; dosage for Novavax: 0.5 mL/5 ug rS protein and 50 ug Matrix-M adjuvant; dosage for Pfizer-BioNTech: 0.3 mL/30 ug.
‡The recommended interval for Moderna (mNexspike) is 3 months after the last dose; however, a dose administered at least 2 months after the last dose should not be repeated.
1e: Ages 65 years and olderNOTE
Moderna (mNexspike), Moderna (Spikevax), Novavax, and Pfizer-BioNTech COVID-19 vaccines are approved for this age group.
COVID-19 vaccination history before 2025–2026 vaccine*
Number of 2025–2026 doses indicated
Recommended 2025–2026 vaccine† and interval between doses
Administer 2 doses of 2025–2026 vaccine 2025–2026 Dose 2 (Moderna [Spikevax], Novavax, or Pfizer-BioNTech): 6 months (minimum interval 2 months) after 2025–2026 Dose 1; (Moderna [mNexspike]): 6 months (minimum interval 3 months)‡ after 2025–2026 Dose 1 Administer 2 doses of 2025–2026 vaccine 2025–2026 Dose 2 (Moderna [Spikevax], Novavax, or Pfizer-BioNTech): 6 months (minimum interval 2 months) after 2025–2026 Dose 1; (Moderna [mNexspike]): 6 months (minimum interval 3 months)‡ after 2025–2026 Dose 1
Unvaccinated:
Unvaccinated
2
2025–2026 Dose 1 (Moderna, Novavax, or Pfizer-BioNTech): Day 0
Previously vaccinated before 2025–2026 vaccine:
1 or more doses any COVID-19 vaccine (Moderna, Novavax, or Pfizer-BioNTech)
2
2025–2026 Dose 1 (Moderna [Spikevax], Novavax, or Pfizer-BioNTech): At least 8 weeks after last dose; (Moderna [mNexspike]): At least 3 months after last dose‡
*COVID-19 vaccination history refers to all doses of COVID-19 vaccine from any manufacturer received before the availability of the 2025–2026 COVID-19 vaccines.
†Dosage for Moderna (mNexspike) 0.2 mL/10 ug; dosage for Moderna (Spikevax): 0.5 mL/50 ug; dosage for Novavax: 0.5 mL/5 ug rS protein and 50 ug Matrix-M adjuvant; dosage for Pfizer-BioNTech: 0.3 mL/30 ug.
‡The recommended interval for Moderna (mNexspike) is 3 months after the last dose; however, a dose administered at least 2 months after the last dose should not be repeated.
Self-attestation of COVID-19 risk factors
People can self-attest to factors that increase their risk for severe COVID-19 during the individual-based decision-making process and receive COVID-19 vaccine doses wherever vaccines are offered. Vaccinators should not deny COVID-19 vaccination to a person due to lack of documentation.