欧博官网Sectional Study of Persons Receiving Medical C
Medical Cannabis and Cannabinoids (May 2023)
Protocol of a Combined Cohort and Cross-Sectional Study of Persons Receiving Medical Cannabis in Florida, USA: The Medical Marijuana and Me (M3) Study
Ruba Sajdeya,
Hannah J. Fechtel,
Gabriel Spandau,
Amie J. Goodin,
Joshua D. Brown,
Sebastian Jugl,
Nicole E. Smolinski,
Almut G. Winterstein,
Robert L. Cook,
Yan Wang
Affiliations
Ruba Sajdeya ORCiD Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA Hannah J. Fechtel ORCiD Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA Gabriel Spandau Consortium for Medical Marijuana Clinical Outcomes Research, Gainesville, FL, USA Amie J. Goodin ORCiD Consortium for Medical Marijuana Clinical Outcomes Research, Gainesville, FL, USA Joshua D. Brown Consortium for Medical Marijuana Clinical Outcomes Research, Gainesville, FL, USA Sebastian Jugl ORCiD Consortium for Medical Marijuana Clinical Outcomes Research, Gainesville, FL, USA Nicole E. Smolinski ORCiD Consortium for Medical Marijuana Clinical Outcomes Research, Gainesville, FL, USA Almut G. Winterstein ORCiD Consortium for Medical Marijuana Clinical Outcomes Research, Gainesville, FL, USA Robert L. Cook Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA Yan Wang Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USADOI https://doi.org/10.1159/000530052 Journal volume & issue Vol. 6, no. 1
pp. 46 – 57
Abstract
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Significant knowledge gaps regarding the effectiveness and safety of medical cannabis (MC) create clinical challenges for MC physicians, making treatment recommendations and patients choosing treatment among the growing number of options offered in dispensaries. Additionally, data describing the characteristics of people who use MC and the products and doses they receive are lacking. The Medical Marijuana and Me (M3) Study was designed to collect patient-centered data from MC users. We aim to describe preferred MC use patterns that patients report as “most effective” for specific health conditions and symptoms, identify user characteristics associated with such use patterns, characterize adverse effects, including cannabis use disorder, identify products and patient characteristics associated with adverse effects, describe concurrent prescription medication use, and identify concomitant medication use with potential drug-MC interaction risk. Among MC initiators, we also aim to quantify MC use persistence and identify reasons for discontinuation, assess MC utilization pattern trajectories over time, describe outcome trajectories of primary reasons for MC use and determine factors associated with different trajectories, track changes in concomitant substance and medication use after MC initiation, and identify factors associated with such changes. M3 is a combined study comprised of: (1) a prospective cohort of MC initiators completing surveys at enrollment, 3 months, and 9 months after MC initiation and (2) a cross-sectional study of current MC users. A multidisciplinary committee including researchers, physicians, pharmacists, patients, and dispensary personnel designed and planned study protocols, established study measures, and created survey questionnaires. M3 will recruit 1,000–1,200 participants aged ≥18 years, with ∼50% new and ∼50% current MC patients from MC clinics across Florida, USA. Study enrollment started in May 2022 and will continue until the target number of patients is achieved. Survey domains include sociodemographic characteristics, physical and mental health, cannabis use history, reasons for MC use and discontinuation, MC products and use patterns, concurrent use of prescription medications and other substances, and side effects. Data collected in the M3 Study will be available for interested researchers affiliated with the Consortium for Medical Marijuana Clinical Outcomes Research. The M3 Study and Databank will be the largest cohort of current and new MC users in Florida, USA, which will provide data to support MC-related health research necessary to inform policy and clinical practice and ultimately improve patient outcomes.
Keywords Published in Medical Cannabis and Cannabinoids ISSN 2504-3889 (Online) Publisher Karger Publishers Country of publisher Switzerland LCC subjects Medicine Website https://www.karger.com/mcaAbout the journal