欧博百家乐What class of medication is Ozempic (semaglut

Ozempic Drug Classification

Ozempic (semaglutide) is a GLP-1 receptor agonist (glucagon-like peptide-1 receptor agonist), a class of medications that selectively binds to and activates GLP-1 receptors to regulate blood glucose and promote weight loss.

Mechanism of Action

Semaglutide functions as a GLP-1 analog with 94% sequence homology to human GLP-1, acting through several key mechanisms :

Glucose-dependent insulin secretion: Stimulates insulin release from pancreatic beta cells only when blood glucose is elevated, minimizing hypoglycemia risk

Glucagon suppression: Reduces glucagon secretion in a glucose-dependent manner, decreasing hepatic glucose production

Delayed gastric emptying: Slows the rate at which nutrients enter circulation in the early postprandial phase

Central appetite suppression: Acts on hypothalamic receptors to reduce food intake and promote satiety

Pharmacological Properties

The extended half-life of approximately 1 week allows for once-weekly subcutaneous administration , . This protraction results from albumin binding facilitated by a C18 fatty di-acid modification at position 26, along with stabilization against DPP-4 enzyme degradation through modification at position 8 .

Clinical Classification Context

Within the broader antihyperglycemic medication landscape, GLP-1 receptor agonists like semaglutide represent a distinct drug class separate from :

SGLT2 inhibitors (empagliflozin, canagliflozin, ertugliflozin)

Dual GIP/GLP-1 receptor agonists (tirzepatide) - though related, this represents a separate class with dual receptor activation ,

DPP-4 inhibitors - which should not be combined with GLP-1 receptor agonists

The American Diabetes Association and FDA recognize semaglutide specifically as a GLP-1 receptor agonist indicated for improving glycemic control in type 2 diabetes and, at higher doses (2.4mg weekly), for chronic weight management , .

2026-01-24 12:25 点击量：0