欧博百家乐Triamcinolone: Allergy Uses, Warnings, Side E
Generic Name: triamcinolone
Brand and Other Names: Kenalog-10, Kenalog-40, Zilretta
Drug Class: Corticosteroids
What is triamcinolone, and what is it used for?
Triamcinolone is a synthetic corticosteroid drug used to treat inflammatory conditions that affect the skin, joints, and internal organs. Triamcinolone is a corticosteroid analog with chemical structure similar to the naturally occurring corticosteroid produced by the cortical region of the adrenal gland.
Triamcinolone is a potent anti-inflammatory and immunomodulating drug used to treat acute systemic inflammations from various conditions including autoimmune disorders.
Triamcinolone inhibits inflammatory signals and synthesis and release of inflammatory substances. Triamcinolone binds to and activates glucocorticoid receptors on cell membranes and produces multiple anti-inflammatory processes:
Triamcinolone is typically administered as injections into joints (intraarticular), skin lesions (intralesional), or into the muscle (intramuscular) for severe systemic inflammations when oral therapy is not feasible. Uses of triamcinolone include:
Intraarticular:
Intralesional:
Intramuscular:
Warnings
What are the side effects of triamcinolone?
Common side effects of triamcinolone include:
Menstrual irregularities
Postmenopausal vaginal hemorrhage
Decrease in sperm quantity and motility
Male pattern hair growth in women (hirsutism)
Secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness)
Suppression of growth in pediatric patients
Skin reactions such as:
Suppressed reactions to skin tests
Feeling unwell (malaise)
Headache
Vertigo
Increased intracranial pressure (pseudotumor cerebri)
Nerve inflammation (neuritis)
Nerve disease (neuropathy)
Numbness and tingling (paresthesia)
Convulsions
Depression
Euphoria
Emotional instability
Mood swings
Personality changes
Psychiatric disorders
Insomnia
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
Health News
What are the dosages of triamcinolone?
Injectable Suspension
10 mg/mL (Kenalog-10; intralesional or intra-articular administration)
40 mg/mL (Kenalog-40; IM or intra-articular administration)
80 mg/mL (Kenalog-40; IM or intra-articular administration)
Injectable, Powder for Reconstitution
32 mg/single-dose vial (Zilretta)
When reconstituted, forms an extended-release suspension
Adult:
Rheumatic or Arthritic Disorders
Treatment of rheumatic or arthritic disorders
Kenalog-40: 60 mg intramuscular (IM) every 6 weeks; may be supplemented by additional 20-100 mg IM as needed
Intra-articular/intrasynovial/soft-tissue injection (Kenalog-40): Large joints, 15-40 mg; small joints/tendon sheath inflammation, 2.5-10 mg
Intra-articular injection (Kenalog-10): Large joints, 5-15 mg; small joints, 2.5-5 mg; single injections into several joints, up to a total of 20 mg or more have been given
Dermatoses
Indicated for treatment of steroid-responsive dermatoses
Intralesional injection (Kenalog-10): 1 mg per injection site 1 or more times weekly; not to exceed 30 mg/day
Kenalog-10: Initial dose varies intralesional injection depending on specific disease and lesion being treated; may be repeated at weekly or less frequent intervals; multiple sites may be injected if they are 1 cm or more apart
Inflammatory and Allergic Systemic Conditions
Multiple Sclerosis
Kenalog-40 or Kenalog-80: 160 mg IM every day for 1 week, followed by 64 mg every other day for 1 month
Osteoarthritis (Zilretta)
Dosing Considerations
Not interchangeable with other formulations of injectable triamcinolone acetonide
Not suitable for use in small joints (e.g., hand)
Limitations of use
Efficacy and safety of repeat administration of Zilretta have not been demonstrated
Pediatric:
Kenalog only; Zilretta safety and efficacy not established
Rheumatic or Arthritic Disorders
Treatment of rheumatic or arthritic disorders
Neonates: Not for use in neonates (contains benzyl alcohol)
Children 6-12 years: 0.03-0.2 mg/kg IM every 1-7 days
Children above 12 years: 60 mg IM every 6 weeks; may be supplemented by additional 20-100 mg IM as needed
Children 12 years, intralesional injection (10 mg/mL suspension): 1 mg per injection site 1 or more times weekly; not to exceed 30 mg/day
Inflammatory and Allergic Systemic Conditions
Initial dose of triamcinolone may vary depending on specific disease entity being treated
0.11-1.6 mg/kg/day IM divided every 3-4 hours
Overdose
Triamcinolone is administered as an injection in a clinical setting and acute overdose is unlikely.
For chronic overdose because of severe disease requiring continuous steroid therapy, the dosage of the corticosteroid may be reduced only temporarily, or alternate day treatment may be introduced.
Overdose treatment is symptomatic and supportive therapy.
What drugs interact with triamcinolone?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
Triamcinolone has serious interactions with at least 72 different drugs.
Triamcinolone has moderate interactions with at least 229 different drugs.
Triamcinolone has mild interactions with at least 121 different drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
What else should I know about triamcinolone?
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Summary
Triamcinolone is a synthetic corticosteroid drug used to treat inflammatory conditions that affect the skin, joints, and internal organs, and autoimmune disorders. Common side effects of triamcinolone include joint swelling, bruises (contusions), cough, sinus inflammation (sinusitis), irregular heart rhythm (cardiac arrhythmia), slow or rapid heart rate (bradycardia or tachycardia), heart enlargement (cardiomegaly), high blood pressure (hypertension), cardiac failure, heart muscle rupture, thickened heart muscle (hypertrophic cardiomyopathy) in premature infants, cerebrovascular accident, circulatory shock, blood vessel inflammation (vasculitis), blood clot block in blood vessels (thromboembolism), and others.
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