欧博官网Amoxicillin Interactions: Other Medications, A
Amoxicillin (Amoxil) may interact with other medications. For example, it can interact with blood thinners and birth control pills.
Amoxicillin is a generic prescription drug used in adults and some children to treat infections caused by certain bacteria.
Amoxicillin is available as the brand-name drug Amoxil.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions. Keep reading to learn about amoxicillin’s possible interactions. For a detailed overview, check out this in-depth amoxicillin article.
Does amoxicillin interact with other drugs?
Before you start taking amoxicillin, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether amoxicillin interacts with herbs, vitamins, or supplements, see the “Are there other interactions with amoxicillin?” section.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The following table lists drugs that may interact with amoxicillin. Keep in mind that this table does not include all drugs that may interact with amoxicillin. For more information about some of these interactions, see the “Drug interactions explained” section.
Drug group or drug nameDrug examplesWhat can happen
methotrexate (Trexall, others) — can increase the risk of side effects from methotrexate
warfarin (Jantoven) — can increase the risk of bleeding
birth control pills • ethinyl estradiol/drospirenone (Yaz)
• ethinyl estradiol/norgestimate (Sprintec) can make birth control pills less effective
certain gout medications • probenecid (Probalan)
• allopurinol (Zyloprim) can increase the risk of side effects from amoxicillin
When should I avoid amoxicillin?
Certain health conditions or other factors could increase your risk of harm if you take amoxicillin. These are known as contraindications. In such cases, your doctor may not prescribe this medication for you.
Amoxicillin has one contraindication, which is a past allergic reaction to amoxicillin or any of its ingredients.
If you’ve had an allergic reaction to amoxicillin or to similar antibiotics, such as penicillins or cephalosporins, your doctor likely won’t prescribe this medication for you. This is because taking amoxicillin can cause another allergic reaction. Your doctor can tell you about other treatments that may be better options.
Does amoxicillin interact with alcohol?
Amoxicillin is not known to interact with alcohol. But amoxicillin and alcohol can cause some similar side effects, such as diarrhea, vomiting, and nausea. So combining alcohol and amoxicillin may raise your risk of experiencing these side effects, or it could make the side effects worse.
If you have questions about consuming alcohol while taking amoxicillin, talk with your doctor or pharmacist.
Drug interactions explained
Learn more about certain drug interactions that can occur with amoxicillin.
Interaction with birth control pills
Taking amoxicillin with birth control pills can make the birth control less effective. This is because amoxicillin can interfere with the absorption of birth control pills into your body. This leads to a lower level of the birth control drug in your system, making the medication less effective.
Examples of birth control pills that may interact with Amoxicillin include:
ethinyl estradiol/drospirenone (Yaz)
ethinyl estradiol/norgestimate (Sprintec)
ethinyl estradiol/desogestrel (Mircette)
ethinyl estradiol/levonorgestrel (Levora)
What you can do
If you take birth control pills, talk with your doctor before you start taking amoxicillin. They will likely recommend a backup method of birth control, such as condoms, during amoxicillin treatment and for at least 7 days after your last dose.
If you have questions about taking amoxicillin with birth control pills, talk with your doctor or pharmacist.
Interaction with warfarin
Taking amoxicillin with the blood thinner warfarin (Jantoven) can increase your risk of bleeding.
Amoxicillin can alter your gut bacteria. These bacteria help your body make vitamin K, which plays a vital role in forming blood clots.
Because amoxicillin can alter gut bacteria, it can also interfere with your body’s ability to make vitamin K. This can increase your risk of bleeding, especially if you take amoxicillin with warfarin.
What you can do
If your doctor has you take amoxicillin with warfarin, they may prescribe a lower dosage of warfarin for you. You should not take a higher dose of either medication than your doctor prescribes.
If you take amoxicillin and warfarin together, tell your doctor right away if you have symptoms of bleeding. These may include unexplained bruising, nosebleeds, and blood in your urine or stool.
If you have questions about taking these drugs together, talk with your doctor or pharmacist.
Interaction with methotrexate
Combining amoxicillin and methotrexate (Trexall, others) can increase the risk of side effects from methotrexate. This is because amoxicillin can increase the level of methotrexate in your system, which raises your risk of side effects from the drug. Examples of these side effects include bleeding, skin rash, and diarrhea.
What you can do
If you take amoxicillin with methotrexate, your doctor will likely monitor you more frequently for side effects during treatment. They may also adjust your dosage of methotrexate.
If you have questions about taking amoxicillin with methotrexate, talk with your doctor or pharmacist.
Are there other interactions with amoxicillin?
Amoxicillin may have other interactions. They could occur with supplements, foods, vaccines, or lab tests.
The following sections describe additional interactions that may occur with amoxicillin. Note that this information does not include all other possible interactions with amoxicillin.
Does amoxicillin interact with supplements?
Before you start taking amoxicillin, talk with your doctor and pharmacist about any herbs, vitamins, or supplements you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Amoxicillin interactions with herbs
There are currently no reports of amoxicillin interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.
For this reason, it’s important to check with your doctor or pharmacist before taking any of these products while taking amoxicillin.
Amoxicillin interactions with vitamins
There are currently no reports of amoxicillin interacting with vitamins. But such interactions could be recognized in the future.
For this reason, it’s important to check with your doctor or pharmacist before taking any of these products while taking amoxicillin.
Does amoxicillin interact with food?
There are currently no reports of amoxicillin interacting with food. If you have questions about eating certain foods during treatment with amoxicillin, talk with your doctor.
Does amoxicillin interact with vaccines?
You should not receive the live typhoid vaccine during your amoxicillin treatment or in the 24-hour period after your last dose.
The typhoid vaccine contains weakened versions of Salmonella typhi, the bacteria it is meant to protect against. Amoxicillin is known to protect against this bacteria. This means receiving the typhoid vaccine while you’re taking amoxicillin can make the vaccine less effective.
If you need to receive the typhoid vaccine, talk with your doctor first to make sure it’s safe.
Does amoxicillin interact with lab tests?
Amoxicillin can interact with certain types of urine glucose tests. Having this test done while you’re taking amoxicillin can cause a false-positive result. In this case, a false-positive result may indicate that you have a high blood sugar level, even if you don’t.
Tell your doctor you’re taking amoxicillin before having a urine glucose test. They may recommend a different type of test.
Does amoxicillin interact with cannabis or CBD?
There are currently no reports of amoxicillin interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with amoxicillin.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Does my health history affect whether I should take amoxicillin?
Certain medical conditions or other health factors may raise the risk of interactions with amoxicillin. Before taking amoxicillin, talk with your doctor about your health history. They’ll determine whether amoxicillin is right for you.
Health conditions or other factors that might interact with amoxicillin include:
Severe kidney problems: If you have severe kidney problems, such as chronic renal failure, talk with your doctor before taking amoxicillin. Your kidneys help clear amoxicillin from your system. If you have kidney problems, the drug can build up in your body and increase your risk of side effects. Because of this, your doctor may prescribe a lower dosage of the drug or recommend a different treatment.
Mononucleosis: If you have mononucleosis (a viral infection), taking amoxicillin can increase your risk of a severe rash. If you have mononucleosis, let your doctor know before starting amoxicillin treatment. They’ll likely prescribe a different medication.
Pregnancy: Amoxicillin is generally considered safe to take during pregnancy. But if you’re pregnant or planning a pregnancy, you should still talk with your doctor before taking amoxicillin. They can determine whether it’s safe for you to take.
Breastfeeding: It’s not known whether it’s safe to take amoxicillin while breastfeeding. The drug passes into breast milk and can cause mild side effects in a child who is breastfed. If you’re breastfeeding or planning to do so, talk with your doctor about your options.
Allergic reaction: If you’ve had an allergic reaction to amoxicillin or to similar antibiotics, such as penicillins or cephalosporins, your doctor likely won’t prescribe this medication for you. This is because taking amoxicillin can cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.
How can I prevent interactions?
Taking certain steps can help you avoid interactions with amoxicillin. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
It’s also important to understand amoxicillin’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. The paperwork, sometimes called the patient package insert or medication guide, may have other details about interactions.
If you did not get paperwork with amoxicillin, ask your pharmacist to print a copy for you. If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking amoxicillin exactly as prescribed can also help prevent interactions.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.